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A construct containing human exon 5 followed by the entire human CBFA2T1 coding region was inserted at the endogenous locus via homologous recombination, replacing the endogenous exon 5. The targeted allele generates a fusion protein similar to the fusion protein resulting from T(8;21) which is associated with the M2 subtype of acute myeloid leukemia (AML). Transcription of the allele was verified in heterozygous mice by a protection assay. (J:38705)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
