Log In|Sign Up
EN
Exons 1 and 2 were replaced with an IRES-lacZ-floxed-neo cassette via homologous recombination. The floxed neo cassette was removed in correctly targeted ES cells by transient expression of cre recombinase. Absence of gene expression in homozygous mutant animals was demonstrated by Western blot of hindbrain and forebrain extracts using anti-POMA antisera which recognizes all species of nova proteins. The Nova1-specific band was not observed in samples from homozygous mutants. (J:60771)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
