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The endogenous gene was targeted with a construct in which codon 217 had been modified by site directed mutagensis to encode glycine rather than valine. The targeted residue (corresponding with Val 205 in the human protein) lies within the N finger domain and is involved in zinc finger protein binding. A floxed neo cassette was inserted in the intron following the exon containing the substitution mutation. Comparision with mice carrying Gata4tm1.1Sho indicated that the intronic neo cassette did not affect gene expression. (J:77392)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
