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The first coding exon was replaced with a neomycin resistance gene via homologous recombination. Immunoprecipitation and Western blot analysis using an antibody directed against the C-terminus of the protein did not detect wild-type gene product in homozygous mutant animals. However, a smaller protein was detected at low levels, possibly produced from residual transcripts. Il4-induced DNA-binding activity of Stat6 was not present in homozygous mutant animals. (J:32607)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
