Rpgr^tm1Tili

Part of exon 4 through part of exon 6 was replaced with a promoter-less lacZ-neo cassette via homologous recombination. Northern blot analysis using a full length cDNA probe did not detect gene expression in brains from homozygous mutant animals. RT-PCR analysis also did not detect gene transcripts. Western blot analysis of protein from brain, retina, and testis confirmed the null allele. (J:61371)