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Exon 4 was replaced by a PGK-neo cassette inserted by homologous recombination. Circular transcripts were undetected by RT-PCR analysis of brain and kidney samples obtained from homozygous mutant mice. Ribonuclease protection assays showed that transcripts lacking the targeted exon were present at normal levels in homozygous mutant mice. Corresponding results were obtained by Western blot analysis. (J:50647)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
