Most of the gene was deleted by replacement of a 2.2 kb region containing the 5' untranslated region and 634 bp of coding sequences with a neomycin resistance cassette via homologous recombination. Homozygous mutant embryos were observed by PCR genotype analysis up to day E9.5. In situ hybridization did not detect gene expression in homozygous mutant embryos. (J:61449)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intragenic deletion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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