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1,126 bp of the gene, including part of exon 2 and part of exon 3, was replaced with a PGK-neo cassette via homologous recombination. The targeted mutation disrupts the transmembrane domain and the 5'-3' phosphoadenosine 5'-phosphosulfate-binding motif. Northern blot analysis of brain RNA and RT-PCR analysis of testicular RNA showed that gene expression is abolished in homozygous mutant animals. (J:78560)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
