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A portion of exon 2 and all of exon 3 were replaced with a neomycin selection cassette. Transcript was undetected by RT-PCR analysis of total lung RNA obtained from homozygous mutant mice. The absence of protein was verified by Western blot analysis of lung lysates and immunohistochemical analysis of bronchiolar epithelial cells. Analysis of prostate and uterine tissue obtained from homozygous mutant mice yielded corroborative results. (J:40748)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
