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Exons 3 and 4 were deleted by the insertion of a floxed neo cassette, which was subsequently excised via the in vitro expression of cre recombinase. The targeted region encoded the transmembrane domain and a portion of the cytoplasmic domain including the first tyrosine of the immunoreceptor tyrosine-based activation motif (ITAM). The ablation of protein expression in homozygous mutant mice was confirmed via immunohistochemical analysis of spleen sections. (J:64763)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
