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3.5 kb of the gene, a region including exon 24, was replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis showed an absence of C3 beta-chain protein in the serum of homozygous mutant animals. Similarly, ELISA assay did not detect C3 protein in serum from homozygous animals. (J:45857)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
