The gene was disrupted by replacement of sequences encoding all of the zinc finger motifs with a floxed neomycin-cytidine deaminase cassette. The floxed cassette was removed by crossing mutant animals to a cre deleter strain. Homozygous mutant embryos were detected by Southern blot analysis up to day E15.5. RNase protection assay showed an absence of Zfpm2 mRNA in hearts of E12.5 homozygous mutant embryos. (J:62879)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
Insertion, Intragenic deletion
--
1
7
15

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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