A construct, in which a 0.5 Kb fragment extending from upstream of the TATA box through codon 117 was replaced with a neomycin selection cassette, was inserted at the endogenous locus via homologous recombination. No immunoreactivity was observed in testes sections obtained from homozygous mutant mice. (J:67063)
Basic Information
Disruption caused by insertion of vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count