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A loxP site was introduced ~900 bp upstream of exon 1 and a loxP-flanked neomycin resistance cassette 120 bp downstream of exon 2. Cre recombinase deleted exons 1 and 2, encoding the first 33 amino acids of the protein, and the selection cassette, leaving behind a single loxP site. This allele was derived from the same targeting event as Col15a1tm2.1Pih. The absence of transcript and protein was verified by Northern blot and immunohistochemical analyses of homozygous mutant mice. (J:67212)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
