This allele is a derivative of Eportm1.3Jtp in which cre-mediated recombination in vivo removed the PGK-neo cassette in the germline. The resulting allele, Eportm1.4Jtp, contains human sequence carrying a C5964G transversion mutation in exon 8. RT-PCR analysis of bone marrow detected truncated human transcript in homozygous mutant mice. (J:67205)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd-Hprt1b-m3
Targeted
Insertion, Intragenic deletion
--
1
1
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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