Sequence extending from within exon 2 to within exon 4 was replaced with a cassette containing the lacZ and neo genes. The deleted region encoded amino acids 86 through 166, which make up the nuclear localization signal and the DNA binding and dimerization domains. Expression of beta-galactosidase was determined to be driven by the endogenous promoter. (J:67376)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
Insertion, Intragenic deletion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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