A neomycin selection cassette was inserted into the terminal exon which encodes the DNA binding and leucine zipper domains. Northern blot and RT-PCR analysis demonstrated that a mutant 7 kb transcript was expressed from this allele, but immunoblot analysis confirmed that no detectable protein was encoded by this allele. (J:46990)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
Insertion
--
1
--
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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