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A cassette containing NLS-lacZ and neo genes was inserted downstream of the translational start codon in exon 2 via homologous recombination. Normal transcript was undetected by RT-PCR analysis of heart, skeletal muscle, and bladder tissue obtained from homozygous mutant mice. Although the 5' UTR and all intronic sequences were left intact, the expression of beta-galactosidase did not completely correlate with that of the endogenous gene. (J:74656)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
