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The floxed sequences of Dmrt1tm1Zark were deleted by mating mice carrying this allele to the cre-expressing TgN(ACTB-cre)2Mrt line. The cre-mediated recombination event removes the promoter, the major translation initiation codon, exon 1 (which contains the zinc-finger-like DM domain), the neomycin resistance gene, and part of intron 1. Homozygous mutant animals did not express protein product as demonstrated by immunohistochemical analysis of testes sections. (J:65541)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
