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The transgene is comprised of a dominant negative mutant Casp1 gene carrying a cysteine to glycine substitution at position 285 (C285G) fused to lacZ and the enolase 2 promoter. The enolase 2 promoter was used to direct expression of the transgene to cells of the nervous system. Transgenic animals were identified by PCR genotyping. X-gal staining of transgenic tissues detected transgene expression in the dorsal root ganglion. (J:38779)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
