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1.3 kb of truncated human FGFR2-IIIb cDNA deleted for kinase domains 1 and 2 was used as the transgene. Deletion of the kinase domains results in a dominant negative protein which blocks FGF receptor signaling. The transgene is expressed in developing airway epithelium under the direction of the human SFTPC promoter. Expression of the transgene was detected in the distal epithelial cells of the lung via in situ hybridization analysis. (J:19481)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
