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This mutation is derived from Pik3cdtm1Bvan. Chimeric animals carrying Pik3cdtm1Bvan were crossed to a cre-expressing line to remove the floxed lacZ-neo cassette. The D910A mutation is left intact. Western blot analysis demonstrated the expression of mutant protein in thymocytes is similar to that of wild-type protein. Immunoprecipitates from homozygous mutant animals showed that mutant proteins were completely devoid of kinase activity. (J:78412)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
