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A genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a 600bp fragment of the rat insulin promoter and to the mouse H2-Kb transmembrane sequence (which included the extracellularspacer sequence, transmembrane segment, and cytoplasmic tail). The rat insulin promoter was used to direct expression of the inserted sequence specifically to pancreatic islet beta cells. Islets from mice carrying the transgene showed expression of chicken lysozyme by Western blot; spleen, thyroid, and thymus did not. (J:78309, J:156091)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
