Tg(Camk2a-Grin2b)1Jzt

The transgene consists of the full Grin2b gene driven by 8.5 kb of Camk2a promoter, active in the mouse forebrain. Northern blot analysis demonstrated enrichment of gene expression in the cortex and hippocampus of transgenic animals and Western blot analysis demonstrated 2X protein over-expression compared to wild-type animals. Furthermore, in situ hybridization showed enrichment of the transgene in the cortex, striatum, hippocampus, and amydala. A slight increase in expression of Grin1 protein was also detected. (J:57250)