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Sequence encoding the basic helix-loop-helix domain was disrupted by the insertion of a construct containing lacZ followed by a floxed neo cassette via homologous recombination. The neo cassette was excised by the transient transfection of targeted ES cells by cre recombinase. Expression of lacZ was visualized via Xgal staining. (J:48084)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
