A construct, in which Exon 2 was flanked by a loxP site inserted into intron 1 and a floxed neo cassette ineserted into intron 2, was incorporated at the endogenous locus by homologous recombination. (J:75116)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count