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0.82 kb of human BCL2L1 cDNA preceded by 12.9 kb of rat insulin promoter and enhancer sequences was used for the transgene. Specific expression of the transgene in beta-cells of the pancreas was confirmed by immunohistochemical analysis. Protein staining was detected in beta-cells of transgenic animals, but not in non-beta-cells, liver, exocrine tissue, small intestine, or lymph nodes. Western blot analysis showed expression of the human protein is at least 10-fold greater that of endogenous protein. (J:78000)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
