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The human gastrin gene engineered with a stop codon after glycine 72 and under the control of the mouse metallothionein promoter was used as the transgene. The transgene was verified by Southern blot analysis using a human gastrin exon 2 probe. Northern blot analysis detected transgene expression in kidney, liver, colon, stomach, and pancreas of transgenic animals using the exon 2 probe. RT-PCR analysis confirmed the expression of transcripts truncated after codon 72 in the colon of transgenic animals. (J:54869)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
