The coding exon of the enodogenous allele was flanked by an upstream loxP site and a downstream floxed neo cassette. Transient expression of cre recombinase in ES cells resulted in the excision of the neo cassette, leaving a floxed coding exon. (J:78265)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count