A loxP site was introduced 1 kb upstream of exon 2 and a floxed PGK-neo cassette was introduced 0.75 kb downstream of exon 2 via homologous recombination. Exon 2 encodes the DNA-binding domain of the gene. (J:75777)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count