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This mutation is a deletion of the three CTC nucleotides of codon 49 and replacement of these with two TA nucelotides. This alters a serine residue to a methionine with a shift in the reading frame for the remainder of the encoded protein. Transcript expression levels from this allele are reduced 4-fold relative to wild-type. (J:75206)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
