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Part of exon 6 and all of exon 7 were replaced with a PGK-neo cassette in the opposite orientation via homologous recombination. The targeted mutation results in deletion of amino acids 164-214 and introduces multiple stop codons into exon 6. Homozygous mutant embryos were observed between E5.5 and E7.5 via Southern blot analysis. (J:49531)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
