The insertion of a neomycin selection cassette replaced exon 4 and precluded the complete translation of proteins initiated from a potential start codon at position 59 in the 3' terminal of exon 2. Normal protein was undetected by Western blot analysis of homozygous mutant mice, however, the lack of truncated carboxy terminal peptides was not directly verified. (J:16994)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1+
Targeted
Insertion, Intragenic deletion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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