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A stop codon was introduced at position 292 to shorten the protein by 7 residues, 2 of which are in the essential domain. Expression and sequence analysis showed message to be transcribed and processed properly in homozygous mutant mice. RT-PCR analysis revealed levels of transcript to be approximately 15% of those in wild-type mice. Further analysis showed that transcription of the antisense gene was unaffected by the targeting event. (J:41161)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
