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A 2.8 kb region of the gene encompassing part of exon 1, exon 2, and exon 3 was replaced with a PGK-neo cassette via homologous recombination. The targeted region encodes the translation initiation codon and the first of 3 zinc finger domains. Northern blot analysis and immunohistochemistry of skin sections from homozygous mutant animals verified the absence of gene expression. (J:56495)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
