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The human APOB gene (~19 kb of genomic sequence 5' to the translational start site of the gene and ~14kb of genomic sequence 3' to the transcription termination site) was introduced into fertilized FVB mouse embryos. Multiple lines were generated, ranging in copy number from 1 to 11 for the human gene, by Southern blot. This transgene is the high-expressing line, with an estimated eleven copies of the APOB gene in liver of these mice. (J:78212)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
