Log In|Sign Up
EN
This allele was generated by breeding mice carrying Lattm2Lov with transgenic mice expressing cre recombinase via the EIIa promoter. Expression of cre resulted in the excision of the floxed neo cassette, leaving the tyrosine to phenylalanine mutations at positions identified as being critical for the binding of signaling molecules (136, 175, 195, and 235) intact. Flow cytometric analysis of thymocytes from homozygous mutants showed reduced levels of protein. (J:77695)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
