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Tyrosine to phenylalanine mutations were introduced at positions identified as being critical for the binding of signaling molecules (136, 175, 195, and 235) via site-directed mutagenesis. A floxed neomycin selection cassette was inserted downstream of the coding region. Mice carrying this allele were bred with transgenic mice expressing cre recombinase via the EIIa promoter to generate Lattm2.1Lov. (J:77695)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
