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The endogenous locus was disrupted by the insertion of a tau-lacZ cassette at the start codon by homologous recombination. A floxed neo cassette that was included in the targeting vector was excised via in vivo cre mediated recombination, leaving a single loxP site immediately downstream of the tau-lacZ sequence. Normal transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:78008)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
