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The endogenous locus was disrupted by the insertion of a tau-lacZ cassette at the start codon by homologous recombination. A floxed neo cassette that was included in the targeting vector was excised via in vivo cre mediated recombination, leaving a single loxP site immediately downstream of the tau-lacZ sequence. Normal transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:78008)