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A 1.5 kb region of the gene containing exon 2 was replaced with a PGK-neo cassette via homologous recombination. Exon 2 encodes the translation start site and the entire octapeptide region of the protein. Absence of gene expression was confirmed in homozygous mutant animals by Northern blot analysis of liver tissue. Furthermore, no plasma angiotensinogen could be detected in homozygous mutant animals. (J:30061)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
