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The gene was disrupted by replacement of exons 2-4 with a PGK-neo cassette via homologous recombination. The null allele was confirmed by Western blot analysis of mouse embryonic fibroblasts (MEFs) derived from E14.5 homozygous mutant embryos. No protein expression was detected. (J:76248)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
