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A cassette, containing a promoterless lacZ and neo, was inserted immediately downstream of the endogenous start codon. Western blot analysis of protein extracts obtained from cerebrum, cerebellum, and spinal cord tissue showed an absence of encoded protein in homozygous mutant mice. The expression pattern of beta-galactosidase showed a strong correlation to that of the endogenous gene. (J:22502)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
