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The exon containing the entire coding region of the gene was replaced with a GFP-PGK-neo cassette via homologous recombination. In situ hybridization analysis of E10.5 embryos demonstrated the absence of gene expression in homozygous mutants. GFP transcripts were detected in mutant animals in a pattern indistinguishable from the endogenous mRNA but no fluorescent signal could be detected. (J:46668)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
