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A 700 bp genomic fragment containing part of exons 2 and 3 was replaced with a neomycin selection cassette. RNase protection analysis on RNA derived from skeletal muscle and brown adipose tissue of homozygous mice confirmed that no detectable transcript was expressed from this allele. Western blot analysis confirmed the absence of detectable protein in skeletal muscle mitochondria of homozygous mice. (J:62313)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
