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The exon encoding N-terminal residues 82-118 was replaced with a neomycin resistance gene via homologous recombination. Western blot analysis of brain membrane fractions from homozygous mutant animals did not detect protein product. Whole cell voltage clamp analysis of thalamocortical relay neurons from homozygous mutants detected no calcium current thus confirming the functional ablation of the protein. (J:70557)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
