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As a result of incorrect gene targeting, a neomycin resistance cassette inserted between exons 2 and 3 via homologous recombination. A decrease in gene expression in homozygous mutants was observed by RT-PCR analysis of total midbrain RNA using primers to exons 2 and 12. Western blot analysis of striatal membrane extracts from homozygous mutants showed greater than 95% decrease in protein expression compared to wild-type. (J:70606)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
