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Part of exon 4 and all of exons 5-7 were replaced with a neomycin resistance gene via homologous recombination resulting in deletion of the last zinc finger domain and the entire TRAF domain. Absence of gene expression in homozygous mutants was verified by Western blot analysis of mouse embryonic fibroblast (MEFs) derived from E12.5 embyros. (J:76067)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
