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The locus was disrupted by the insertion of a construct, containing a floxed neo gene and a lacZ gene fused to the transmembrane domain of the mouse Ntrk2 gene. The insertion was made just downstream of the sequences encoding the signal peptide. RT-PCR analysis confirmed the absence of transcript in homozygous mutant mice. Staining of heterozygous embyros showed expression of beta-galactosidase. (J:53085)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
