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The promoter and first 2 exons were replaced with an Hprt cassette via homologous recombination. Northern blot of homozygous mutant animals showed complete absence of gene expression. Western blot analysis of skin protein extracts from homozygous mutants showed lack of protein expression. (J:76311)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
