A FRT-flanked neomycin resistance cassette driven by beta-actin replaced exon 18, which is specific to the 180 kDa isoform of the protein. Immunoblot analysis of brain tissues from homozygous mutant mice did not detect the 180 kDa isoform in neonatal and adult tissues, and detected the 140kDa isoform in neonatal tissues, but not in adult tissues. (J:37891)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
Insertion, Intragenic deletion
--
1
--
12

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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